Application of Network Pharmacology to Predict the Mechanism of Semen Cassiae#br#
in the Treatment of Hypertension

doi:10. 3969 / j. issn. 2096-2266. 2021. 08. 003

Abstract

Abstract: Objective: To apply network pharmacology to predict the chemical components and mechanism of Semen Cassiae in the
treatment of hypertension. Methods: To search for the chemical constituents and corresponding targets of Semen Cassia through
the TCMSP database, to search for disease-related targets in the GeneCards database, to use Cytoscape 3.6.1 software to create a
drug-component-disease target regulatory network, to use the STRING database to construct protein-protein interaction network , and
to do GO function and KEGG pathway enrichment analyses of Chinese medicine-disease targets through DAVID database. Results:
11 chemical ingredients of Semen Cassia for the treatment of hypertension and 46 effective targets were screened out. The signal
pathways mainly include calcium signal pathway, thyroid hormone signal pathway, and so on. Conclusion: The chemical ingredients in
Semen Cassia may act on ESR1, JUN, MAPK14 and other targets through calcium signaling pathway, and thyroid hormone signaling
pathway to play a hypotensive effect.

Key words: Semen Cassiae, hypertension, network pharmacology

CLC Number:

R285

Gao Xiaomin, Zhao Qin. Application of Network Pharmacology to Predict the Mechanism of Semen Cassiae#br# in the Treatment of Hypertension[J]. Journal of Dali University, 2021, 6(8): 11-15.

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URL: http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/10. 3969 / j. issn. 2096-2266. 2021. 08. 003

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Application of Network Pharmacology to Predict the Mechanism of Semen Cassiae#br# in the Treatment of Hypertension

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